Endocrine Abstracts

Episodic hypercortisolism has been widely described in Cushing’s disease (CD) but is a less commonly recognized presentation of ectopic ACTH syndrome (EAS). We describe 4 cases whose diagnosis and management was complicated by episodic hypercortisolism. These cases highlight diagnostic and therapeutic challenges during the differential diagnosis of CS complicated by intermittent hypercortisolism. All 3 cases of EAS required various combinations of ketoconazole, metyrapone...

Cushing’s disease (CD) may recur despite early remission following transsphenoidal surgery (TSS). We evaluated whether early post-operative serum cortisol (sF) levels on post-operative days 3, 4, 5 predict recurrence.Methods: Patients with CD treated at NIH completed a questionnaire regarding remission status, treatment, and recent biochemistry. We analyzed patients with adenomectomy or hemihypophysectomy at initial TSS, with ACTH-staining tumor and...